Molecular targeting: new therapeutic strategies to improve tumour apoptosis

Molecular pathways: targeting inhibitor of apoptosis proteins in cancer--from molecular mechanism to therapeutic application.

Inhibitor of apoptosis (IAP) proteins play a critical role in the control of survival and cell death by regulating key signaling events such as caspase activation and NF-κB signaling. Because aberrantly high expression of IAP proteins represents a frequent oncogenic event in human cancers, therapeutic targeting of IAP proteins is considered as a promising approach. Several small-molecule pharma...

New strategies in neuroblastoma: Therapeutic targeting of MYCN and ALK.

Clinical outcome remains poor in patients with high-risk neuroblastoma, in which chemoresistant relapse is common following high-intensity conventional multimodal therapy. Novel treatment approaches are required. Although recent genomic profiling initiatives have not revealed a high frequency of mutations in any significant number of therapeutically targeted genes, two exceptions, amplification...

Therapeutic strategies targeting oxidative stress to improve dyslipidemia and left ventricular hypertrophy.

Cardiovascular disease (CVD), the leading cause of premature death worldwide, including in Europe, is predominantly caused by atherosclerosis, a multifactorial disease strongly associated with dyslipidemia. Management of dyslipidemia with statins has resulted in decreases in cardiovascular events and mortality. Unfortunately, although aggressive statin therapy leads to significant reductions in...

CCR New Strategies New Strategies in Neuroblastoma: Therapeutic Targeting of MYCN and ALK

Clinical outcome remains poor in patients with high-risk neuroblastoma, in which chemoresistant relapse is common following high-intensity conventional multimodal therapy. Novel treatment approaches are required. Although recent genomic profiling initiatives have not revealed a high frequency of mutations in any significant number of therapeutically targeted genes, two exceptions, amplification...

Anticancer metal complexes and tumour targeting strategies